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IJAR.2016.428

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Type of Article:  Case Study

Volume 5; Issue 1 (January 2017)

Page No.: 3457-3460

DOI: https://dx.doi.org/10.16965/ijar.2016.428

CHARACTERIZATION OF LOBSTER HAND/FOOT MALFORMATIONS WITH GENETIC EXPRESSION: A FAMILIAL STUDY

M.Yesender, N.Himabindu, S.Saritha, B. Sadananda rao, T.V. Ramani, Nagajyothi.

Department of Anatomy, KAMS & RC, Hyderabad Telangana, India.

Address for Correspondence: Dr. M.Yesender, Department of Anatomy, KAMS & RC, Hyderabad Telangana, India.
E-Mail: matteda.yesender@gmail.com

ABSTRACT:

Introduction: The Lobster Claw Deformity is a form of Ectrodactyly and is a rare combination of ectodermal dysplasia. The Lobster claw deformity is also known as the split hand /foot malformation (SHFM) it is a heterogeneous limb developmental disorder characterized by missing digits and fusion of remaining digits. The pathophysiology of split hand and foot is mainly because of wedge shaped defect of the apical ectoderm of the limb bud.

Aim: The present study aims to provide prominent roots in transmitting and expressivity of lobster claw hand and foot linked to genetic expression.

Materials and Methods: We present two cases of split hand and foot which includes two female siblings aged 7 and 6 years old during routine cases attending the OPD in a private nursing home. The ethical committee permission was taken. Permission was also taken from their parents of respective cases to publish the article.

Conclusion: This scientific paper adopted to illustrate this rare congenital disorder Lobster claw hand/foot malformations. These examples demonstrate understanding of Ectrodactyly coordinating with clinical examination, radiological and genetic investigations.

Key words: Split hand/foot malformation (SHFM), Ectrodactyly, lobster claw hand/foot Autosomal dominant, autosomal recessive.

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Cite this article: M. Yesender, N. Himabindu, S. Saritha, B. Sadananda rao, T.V. Ramani, Nagajyothi. CHARACTERIZATION OF LOBSTER HAND/FOOT MALFORMATIONS WITH GENETIC EXPRESSION: A FAMILIAL STUDY. Int J Anat Res 2017;5(1):3457-3460. DOI: 10.16965/ijar.2016.428