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IJAR.2017.449

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Type of Article:  Original Research

Volume 5; Issue 4.3 (December 2017)

Page No.: 4695-4701

DOI: https://dx.doi.org/10.16965/ijar.2017.449

THE EFFECT(S) OF METHANOLIC LEAF EXTRACT OF BAOBAB ON THE HISTOLOGY OF WISTAR RATS KIDNEYS

Eghoi A.M, Paul, C.W *.

Department of Anatomy, Faculty of Basic Medical Sciences, University of Port Harcourt, Rivers State. Nigeria.

Correspondence: Dr. Paul, C.W,  Department of Anatomy, Faculty of Basic Medical Sciences, University of Port Harcourt, Rivers State. Nigeria.

E-Mail: chikwuogwo.paul@uniport.edu.ng

ABSTRACT

Introduction: The study investigated the effect(s) of methanolic leaf extract of Baobab (MLEB) on the histology of the albino wistar rats’ kidney.

Materials and Method:  Thirty-five (35) albino wistar rats were randomly divided into experimental groups (A-C) of ten rats each and a control group (D) of five rats. Their body weights were measured on a weekly basis throughout the period of the experiment. In addition to standard animal feed and water given to all the groups, experimental groups (A, B and C) were orally administered 40mg/kg, 80mg/kg and 200mg/kg per body weight of MLEB respectively daily for three weeks. During the next four weeks the remaining rats were maintained on standard animal feed and water only, to allow for a wash-out period. The harvest time for Experimental groups were 8th, 15th, 22nd and 50th days, while that of control group was 8th and 50th days. Two rats from each group were harvested, their kidneys and blood samples were used for histologic and biochemical studies respectively. Data was analyzed using One-way ANOVA and SPSS version 2.0. Ethical approval was obtained and the international guidelines for animal studies were obeyed.

Results: it was observed that the body weights of experimental groups were not significantly affected (p<0.05) by the MLEB when compared to control group. Significant histo-pathological changes in the kidney were noticed at the various doses of the MLEB. However, only tissues that received 40mg/kg of the MLEB recovered at the end of wash-out period.

Discussion: The nephrotoxic effect of the MLEB could be attributed to the presence of alkaloids and tannins.

Conclusion: It was concluded that the toxic effect of the MLEB on the kidney was dose-and time-dependent and was only reversible at a low dose. Thus, regular consumption of large quantities of Baobab leaves for prolonged period should be discouraged as it has been shown to possess deleterious effects on the kidney.

Key words: Baobab, Distortion, Glomerulus, Obliteration, Reno-toxic, Reversal.

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Cite this article: Eghoi A.M, Paul, C.W. THE EFFECT(S) OF METHANOLIC LEAF EXTRACT OF BAOBAB ON THE HISTOLOGY OF WISTAR RATS KIDNEYS. Int J Anat Res 2017;5(4.3):4695-4701. DOI: 10.16965/ijar.2017.449