https://www.ijmhr.org/ijar.htm editor_anatomy@ijmhr.org
ISSN:       2321-4281 (E) 2321-8967 (P)

IJAR.2017.456

DOWNLOAD PDF
Table of Contents

Type of Article:  Original Research

Volume 5; Issue 4.3 (December 2017)

Page No.: 4716-4722

DOI: https://dx.doi.org/10.16965/ijar.2017.456

CYTOGENETIC STUDY IN COUPLES WITH BAD OBSTETRIC HISTORY

Vidya H K *1, B S Suresh 2.

*1 Assistant Professor, Department Of Anatomy, Shridevi Institution Of Medical Sciences And Research Hospital, Tumkur, Karnataka, India.

2 Professor, Department Of Anatomy, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

Address for Correspondence: Dr.Vidya H K, Assistant Professor, Department Of Anatomy, Shridevi Institution Of Medical Sciences And Research Hospital, Tumkur-572106, Karnataka, India. E-Mail: vidyassmc@gmail.com

ABSTRACT

Background: Bad obstetric history (BOH) implies previous unfavorable fetal outcome. In couples with bad obstetric history percentage of chromosomal abnormalities varies from
1-25% for individuals. Hence cytogenetic evaluation helps to detect any chromosome defects. This study was done to correlate chromosomal variations with bad obstetric history.

Objective: To study the relation between bad obstetric history and associated chromosomal abnormalities. To study different types of chromosomal abnormalities associated with the bad obstetric history

Materials and Methods: In the present study 60 couples with bad obstetric history were taken up for the study. After taking informed consent, the history and clinical features were noted. Karyotyping was done using standard procedures. Investigations were done to diagnose other associated conditions and were referred to the proper centers for further evaluation and management.

Results: The study was conducted on 60 couples with bad obstetric history, and the following results were obtained. Out of 168 pregnancy losses, 59% of pregnancy loss were in 1st trimester, 17% in second trimester, 12% were IUD’s, 2% were still born, 10% others like died after birth or with congenital anomalies etc…. 17 anomaly cases were recorded in antenatal scan. 24 couples had the history of consanguineous marriage. Cytogenetic evaluation showed . 57 were normal male, 55 were normal female, 4 normal variations, 1 inversion and 2 translocations.

Conclusion: Karyotype analysis in couples with bad obstetric history helps in finding any chromosomal abnormalities, which inturn helps in identification of chromosomal abnormality as the etiology, facilitates genetic counseling and appropriate management.

KEY WORDS: Bad obstetric history ;congenital anomalies; Karyotype; consanguinity; balanced translocation; Robertsonian translocation; mosaicism; inversion; chromosomal variation, genetic counseling.

REFERENCES

  1. Namrata Kumari, Norman Morris and Renu Dutta. Is screening of torch worthwhile in women with bad obstetric history : an observation from Eastern Nepal. J.Health Popul Nutr. 2011 Feb; 29(1):77-80.
  2. L.Rimoin , J.Michael cannor, Reed.E.Pyeritz, Brucer.T.KORF. Emery and Rimons – Principles and Practice of Medical genetics .4th edition. Churchill Livingstone:Elsevier; 2007, p.845-61, 982-92.
  3. Steven G Gabbe, Jennifer.R.Niebyl, Joe Leigh Simpson. Obstetrics normal and problem pregnancies. 5h edition. Churchill livingston an imprint of Elisvier . Piladelphia. Year; 628-45.
  4. Rema Devi, N Sreenivas, Sayee Rajangam. Bad obstetric History and Infectious causes. Int.J Hum Genet. 2002;2(4):269-271.
  5. Dorthy Warburton, Jennie Kline, Zena Stein, Michelle Hutzler, Annie Chin, and Terry Hassold. Does the Karyotype of a spontaneous abortion predict the Karyotype of a Subsequent Abortion? – Evidence from 273 Women with Two Karyotyped Spontaneous Abortions. Am.J.Hum.Genet. 1987;41:465-83.
  6. Ali Mohamad Malekasgar, Mohamad Esmaeil Motlagh, Mahmood Hashemi Tabar, Mohamad Ali Ghafari. Chromosomal analysis of couples with Bad Obstetric History. Iranian Journal of Pathology. 2006;1(3):91-98.
  7. Sayee rajangam, Preetha Tilak, Arun N, Rema Devi. Karyotyping and counseling of bad obstetric history and infertility. Iranian Journal of Reproductive Medicine. 2007;5(1):7-12.
  8. S Dubey, M.R.Chowdhury, B. Prahalad, Kumar, R. Mathur, Hamilton et al. Cytogenetic causes for recurrent abortion an experience of  742 couples [1484             cases]. Indian journal of human genetics. 2005;11(2):94-98.
  9. Dorthy Warburton, Jennie Kline, Zena Stein, Michelle Hutzler, Annie Chin, and Terry Hassold. Does the Karyotype of a spontaneous abortion predict the Karyotype of a Subsequent Abortion? – Evidence from 273 Women with Two Karyotyped Spontaneous Abortions. Am.J.Hum.Genet. 1987;41:465-83.
  10. H. Bittles. The impact of consanguinity on the Indian population. Indian journal of human genetics. 2002;8(2):45-51.
  11. Amudh, N Aruna, S Rajanam. Consanguinity and Chromosomal abnormality. Indian Journal of Human Genetics. 2005;11(2):108-10.
  12. Razieh Dehghani, Firoozabadi, Seyed Mehdi Klantar, Seyed Mohammad Seyed – Hasani, Nasrin Ghasemi et al. Cytogenetic analysis in couples with recurrent spontaneous abortion. Iranian Journal of Reproductive Medicine. 2006 May;4(1):13-17.
  13. Kim HJ, Hsu LYF, Paciuc S, Cristian S, Quintana A,Hirschhorn K : Cytogenetics of fetal wastage. New England Journal of Medicine, 1975;293:844-847.
  14. Hemalatha Purandare, Nandini Baz Fernandes, Sanjay Vasantrao Deshmukh and Sandesh Chavan. Heterochromatic Variations and Pregnancy Losses in Humans. Int J Hum Genet. 2011;11(3):167-75.
  15. Babu V Rao, Lily Kerketta, Seema Korgaonkar, Kanjaksha Ghosh. Pericentric inversion of chromosome 9[inv(9)(912q13)]; its association with genetic diseases. Indian Journal of Human Genetics 2006 September;12(3):129-32.
  16. De Braekeleer M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod 1990;5:519-528.
  17. Dutta U R, P Rajitha, P Vijaya Kumar and Ashwini B Dalal. Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review. J. Assist Reprod Genet 2011;28:145-9.
  18. K.James, P.J.steer, C.P.Weiner, B.Gonik. HIGH RISK PREGNANCY Management options. 3rd edition . Elsevier India private limited New Delhi; 2007.p.43-61,105-21.
  19. Hema Purandarey, Prabodh Mallick, Vishalakshi Mamath, Sadhana Ghaisas. Prenatal Cytogenetic Diagnosis in Couples with Bad Obstetric History – A Study of 1200 Cases. Int J Hum Genet. 2006;(2):50-55.

Cite this article: Vidya H K, B S Suresh. CYTOGENETIC STUDY IN COUPLES WITH BAD OBSTETRIC HISTORY. Int J Anat Res 2017;5(4.3):4716-4722. DOI: 10.16965/ijar.2017.456