https://www.ijmhr.org/ijar.htm editor_anatomy@ijmhr.org
ISSN:       2321-4281 (E) 2321-8967 (P)

IJAR.2018.407

DOWNLOAD PDF
Table of Contents

Type of Article:  Original Research

Volume 7; Issue 1.1 (January 2019)

Page No.: 6071-6074

DOI: https://dx.doi.org/10.16965/ijar.2018.407

PYRETHROIDS EXPOSURE: IMPLICATIONS FOR TESTICULAR DYSFUNCTION IN RATS

Akintunde O.W *1, Olaniyan Lwb 2, Abdulrahman Abdulfatai 1, Yawson E.O 3.

*1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences Ladoke Akintola University of Technology, Ogbomoso.

2 Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences Ladoke Akintola University of Technology, Ogbomoso.

3 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences University of Ilorin.

Corresponding Author: Akintunde O.W, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences Ladoke Akintola University of Technology, Ogbomoso. E-Mail: owakintunde@yahoo.com

ABSTRACT:

Pyrethroids are synthetic pesticides which at low dose of exposure are harmless to humans but at environmentally high concentrations they cause debilitating effects in humans and animals alike. Lack of regulation of the insecticide applications in agriculture and among Nigerian households is therefore a cause for health concern. The reproductive effects of these chemicals are not precisely known. Twenty healthy, sexually active male Wistar rats were randomly divided into four groups. Three groups were exposed to the insecticide in sprayed puffs from the aerosolized insecticide for 15, 30 and 45 seconds/day respectively in air – tight plastic housing for 60 days while one group served as the untreated control. All animals were euthanized via cervical dislocation; the testes were excised and fixed in Bouin’s fluid for routine histological studies using haematoxylin and eosin. The cauda epididymis was also excised for semen quality evaluation. Reduced body weight, alteration of testicular microstructure and significant increase in the proportion of abnormal and non-motile sperm cells were observed in animals exposed to pyrethroid. Exposure to pyrethroid insecticide may lead to body weight loss accompanied with testicular dysfunction possibly leading to sterility in the rats.

Key words: Pyrethroids, Testes, Wistar rats, Reproduction, Insecticide, Sterility.

REFERENCES

    1. Davies TG, Field LM, Usherwood PN, Williamson MS. DDT, pyrethrins, pyrethroids and insect sodium channels. IUBMB Life. 2007;59(3):151-162.
    1. Elliott M. Properties and Applications of Pyrethroids. Environmental Health Perspectives. 1976;14:3-13.
    1. Qualitative Assessment of Impacts of Risk Management Strategies for Endosulfan on Multiple Crops REIs and Cancellation, U.S. Environmental Protection Agency, Washington, DC. USA, 2010.
    1. Spurlock F, Lee M. In synthetic pyrethroids. Gan J., Spurlock F., Dendley P. and Weston D.P. eds. American chemical society. 2008;3.
    1. Toxicological profile for pyrethrins and pyrethroids. U.S. Department of Health and Human Services. Agency for toxic substances and disease registry. Atlanta, GA, USA. 2007.
    1. Shafer TJ, Meyer DA. Effects of pyrethroids on voltage‐sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity. Toxicol Appl Pharmacol. 2004;196:303‐18.
    1. Mikata K, Isobe N, Kaneko H. Biotransformation and enzymatic reactions of synthetic pyrethroids in mammals. Topics in Current Chemistry. 2012;314:113-35.
    1. Eil C, Nisula BC. The binding properties of pyrethroids on human skin fibroblast androgen receptors and to sex hormone binding globulin. J Steroidal Biochem. 1990;35 3(4):409-16.
    1. Tyler CR, Beresford N, van der Woning M, Sumpter JP, Thorpe K. Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities. Environ Toxicol Chem. 2000;19:801-9.
    1. Sun H, Xu XL, Xu LC, Song L, Hong X, Chen JF. Anti-androgenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere. 2007;66(3):474-79.
    1. Meeker JD, Godfrey-Bailey L, Hauser R. Relationships between serum hormone levels and semen quality among men from an infertility clinic. J Androl. 2007;28:397-406.
    1. Zhang SY, Ito Y, Yamanoshita O. Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse. Endocrinology. 2007;148:3941-49.
    1. Turki MAS, Refaat IE. Protective Effects of Vitamin E against testicular Enzymes Toxicity Induced by Cypermethrin in Mice. Int J Pharm Bio Sci. 2013;4(2):942-53.
    1. B A (Baygon Agents). Baygon Accessed online December 21, 2007.
    1. FPA List of Household Pesticides 2002. Accessed online December 21, 2007.
    1. Laboratory Manual for The Examination Of Human Semen And Sperm Cervical Mucus Interaction. 4th Ed. Cambridge: Cambridge University Press. 1999;11:14-17.
    1. Yousef M.I., Salem M.H., Ibrahim H.Z., Helmi S. et al. Toxic effect of carbofuran and glyphosate on semen characteristics in rabbits. J Environ Sci Heal B. 1995;30:513-34.
    1. Rajawat NK, Soni I, Mathur P. et al. Cyfluthrin-induced toxicity on testes of Swiss albino mice. Int J. Curr. Microbiol. App. Sci. 2014;3(3):334-43.
    1. Oda SS, El-Maddawy Z. Protective effect of vitamin E and selenium combination on deltamethrin-induced reproductive toxicity in male rats. Experimental and Toxicologic Pathology. 2012;64:813-19.
  1. Sakr SA, Azab AE. Effects of Pyrethroid Inhalation on the Testes of Albino Rats. Pakistan Journal of Biological Sciences. 2001;4(4):498-500.

Cite this article: Akintunde O.W, Olaniyan LWB, Abdulrahman Abdulfatai, Yawson E.O. PYRETHROIDS EXPOSURE: IMPLICATIONS FOR TESTICULAR DYSFUNCTION IN RATS. Int J Anat Res 2019;7(1.1):6071-6074. DOI: 10.16965/ijar.2018.407