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IJAR.2019.266

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Type of Article:  Original Research

Volume 7; Issue 3.3 (September 2019)

Page No.: 6952-6960

DOI: https://dx.doi.org/10.16965/ijar.2019.266

EFFECT OF FORMALIN ON C REACTIVE PROTEIN AND PULMONARY FUNCTION TESTS IN UNDERGRADUATE MEDICAL STUDENTS IN ANATOMY DISSECTION LABORATORY

Bhagavathiappan G 1,  Manavalan Mahima Sophia *1, Sasirekha M 2.

*1   Professor, Department of Anatomy, ACS Medical College and Hospital, Dr.MGR Educational and Research Institute, Chennai, Tamilnadu, India.

2  Professor and Head, Department of Anatomy, ACS Medical College and Hospital, Dr.MGR Educational and Research Institute, Chennai, Tamilnadu, India

Corresponding Author: Dr.M.Mahima Sophia, Professor, Department of Anatomy, ACS Medical College and Hospital, Dr.MGR Educational and Research Institute,  Chennai-77, Tamilnadu, India. Mobile: +919840319123

E-Mail: mahimasophia1982 @gmail.com

ABSTRACT:

Introduction: Formalin is the commonest fixative chemical used for preserving cadavers by embalming and other biological specimens which is commonly used in Medical colleges in Anatomy Dissection hall. C reactive Protein is an annular pentameric protein found in blood plasma. CRP is synthesised by the liver  and its concentration increases rapidly during inflammatory processes. The aim of the present study is to reveal the correlation between exposure to formalin and changes in pulmonary function tests in undergraduate medical students and to find out the correlation between exposure to formalin and C reactive protein.

Materials and Methods:  The study was conducted on eighty (40 girls and 40 boys) first year undergraduate medical students of both the gender between 18-22 years of age in Department of Anatomy and Physiology, ACS Medical college, Chennai. Pulmonary function tests was carried out by Computerised Spirometer before and after two hours exposure to formalin in the Anatomy dissection hall. Blood sample for serum CRP level estimation was also taken.

Results: There is decrease in values of FVC, FEV1, FEV1/FVC, PEFR and FEF25-75  after 2 hours exposure to formalin. There is decrease in values of FVC, FEV1, FEV1/FVC, PEFR and FEF25-75 in the male participants after 2 hours exposure to formalin  and the only parameter which is  statistically significant is PEFR in the female participants after exposure to formalin. The values of  FEV1 and FEV1/FVC are statistically significant in male and female participants before exposure to formalin. The values of  FEV1/FVC, PEFR and FEF25-75 are statistically significant in male and female participants after exposure to formalin. About 64 students have CRP range of  10.1-40.0mg/l  (80%). About 4 students have more increased levels of CRP within the range of 40.1-80.0 mg/l (5%).

Conclusion: There is great impact of formalin on CRP and Pulmonary function tests in first year undergraduate medical students who are constantly exposed to formalin in Anatomy  dissection laboratory. To avoid this, either protective measures or alternative measures should be taken.

Key words: Embalming, Preservation, Cadaver, Exposure.

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Cite this article: Bhagavathiappan G, Manavalan Mahima Sophia, Sasirekha M. EFFECT OF FORMALIN ON C REACTIVE PROTEIN AND PULMONARY FUNCTION TESTS IN UNDERGRADUATE MEDICAL STUDENTS IN ANATOMY DISSECTION LABORATORY. Int J Anat Res 2019;7(3.3):6952-6960. DOI: 10.16965/ijar.2019.266