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IJAR.2017.113

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Table of Contents

Type of Article:  Original Research

Volume 5; Issue 1 (March 2017)

Page No.: 3579-3586

DOI: https://dx.doi.org/10.16965/ijar.2017.113

Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY

Dinesh Kumar. V *1, Swetasmita Mishra 2, Rima Dada 2.

*1 Assistant Professor, Department of Anatomy, Pondicherry Institute of Medical Sciences, Puducherry, India.

2 Laboratory of molecular reproduction and genetics, All India Institute of Medical Sciences, New Delhi, India.

Corresponding Author: Dr. Dinesh Kumar. V, Assistant Professor, Department of Anatomy, Pondicherry Institute of Medical Sciences, Puducherry, India.  E-Mail: dinesh.88560@gmail.com

ABSTRACT:

Introduction: Male infertility contributes to nearly 30% of the total infertile population worldwide. Genetic factors contribute to about 15% of the causes of male infertility. Systematically elucidating the underlying genetic causes (chromosomal and Yq microdeletion) may help to reduce the number of men with idiopathic infertility and provide them with the most suitable therapeutics and counseling.

Materials and methods: In this study, we performed PCR based screening for AZF microdeletions in 40 men with idiopathic infertility and 40 age-matched fertile men who served as controls.

Results and discussion: Three out of 40 (7.5%) infertile men harboured AZF microdeletions. One patient had AZF b and two patients had AZF c microdeletions.

Conclusion: This genetic evaluation, apart from helping us to decide the treatment option, would also reduce the trauma of repeated ART failure, pregnancy loss, or the stigma of a bearing a physically, mentally, or reproductively challenged offspring.

KEY WORDS: Male infertility, AZF microdeletions, ART failure, reproductively challenged.

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Cite this article: Dinesh Kumar. V, Swetasmita Mishra, Rima Dada. Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY. Int J Anat Res 2017;5(1):3579-3586. DOI: 10.16965/ijar.2017.113