IJAR.2022.238
Type of Article: Original Research
Volume 10; Issue 4 (December 2022)
Page No.: 8496-8504
DOI: https://dx.doi.org/10.16965/ijar.2022.238
Protective Role of Quercetin on Thioacetamide-Induced Renal Injury in Adult Male Albino Rats
Sally Mahmoud Mohamed Hussein omar *1, Marwa Mohamed Abd El Aziz Ahmed 2, Marwa Mahmoud Mady 3.
*1 Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt,
2 Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
3 Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt,
ORCiD:
Sally Mahmoud Mohamed Hussein omar: 0000-0001-6601-4243
Marwa Mohamed Abd El Aziz Ahmed: 0000-0003-4230-7775
Marwa Mahmoud Mady: 0000-0003-2318-7368
Corresponding author: Dr. Sally Mahmoud Mohamed Hussein Omar, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
E-Mail: saliy.hessen@alexmed.edu.eg
ABSTRACT
Background: Thioacetamide (TAA) is a recognized industrial poisonous agent drastically used in animal studies for induction of hepatic necrosis, fibrosis and cirrhosis. It is additionally reported to be nephrotoxic through induction of oxidative stress. Quercetin (QE) has a high antioxidant capacity via free radical scavenging, transition metal ion binding, and lipid peroxidation inhibition.
Aim of the work: The goal of this research was to see if QE may help reduce the negative effects of thioacetamide on renal tissue by histological examination of the kidney.
Material and methods: Twenty-four adult male Albino rats 7–9 weeks old around 180–200g body weight were allocated into 3 groups; Group I (n=8) receiving distilled water, Group II (n=8); rats receiving TAA and Group III (n=8); receiving TAA and QE.
Results: Renal tissues were examined under a light microscope stained by Harris Hematoxylin & Eosin (H&E stain), Periodic acid Schiff (PAS), and Masson’s Trichrome for TAA-treated groups revealed severe histopathological changes, whereas specimens obtained from QE-treated groups showed only mild changes. Immunohistochemical results corroborated these findings.
Conclusion: This study demonstrated the ameliorative consequences of QE in opposition to TAA-induced renal injury in rats. The result of this study might contribute in the development of a novel complementary alternative medication in combating and therapeutic intervention of TAA-induced renal injury.
Key words: Thioacetamide, renal, quercetin, albino rat and histopathology.
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