https://www.ijmhr.org/ijpr.html editor_physiotherapy@hotmail.com
ISSN:       2321-1822 (E) 2321-8975 (P)

IJPR.2021.167

DOWNLOAD PDF
Table of Contents

Type of Article:  Original Research

Volume 9; Issue 5 (October 2021)

Page No.: 3986-3991

DOI: https://dx.doi.org/10.16965/ijpr.2021.167

Pulmonary functions in kidney transplant recipients: Single centre observational study

Harda Shah *1, Nehal Shah 2.

*1 Senior lecturer of physiotherapy, IKDRC-ITS, PhD scholar, Gujarat University, Ahmedabad, Gujarat, India.

2 Principal I/c, SBB College of physiotherapy, Ahmedabad, Gujarat, India.

Corresponding author: Dr. Harda Shah PT, Senior Lecturer Of Physiotherapy, IKDRC-ITS, Civil Hospital Campus, Ahmedabad, Gujarat, India, 380016. E-Mail: hardahshah@gmail.com

ABSTRACT

Background: Kidney transplantation in India is steadily increasing with advancement in medicines and surgical expertise. Subjects with kidney disease have spectrum of pulmonary pathologies but little is known regarding status on pulmonary function after kidney transplantation.

Method: 149 kidney transplant recipients between 18 to 60 years of age, having stable graft function and more than 6months of post-transplant duration were included in the study. Forced vital capacity (FVC), forced expiratory volume in first second (FEV1), the ratio of FEV1/FVC and peak expiratory flow rate (PEFR) were evaluated.

Result: 11 (7.4%) had a restrictive ventilatory impairment, none had obstructive lung function. FEV1 and FVC were lower among subjects with high waist circumference, over weight and obese. FEV1/FVC ratio were lower in subjects with comorbidities or physical inactivity.

Conclusion: Restrictive lung functions present in few kidney transplant recipients. High waist circumference, over weight, obesity, comorbidity and physical inactivity alters pulmonary functions in kidney transplant recipients.

Key words: Kidney transplantation, pulmonary function test, anthropometry, physical activity, comorbidity.

REFERENCES

[1]. Transplantation – WHO, https://www.who.int › topics › transplantation
[2]. Grinyó JM. Why is organ transplantation clinically important? Cold Spring Harb Perspect Med. 2013 Jun 1;3(6):a014985. doi: 10.1101/cshperspect.a014985. PMID: 23732857; PMCID: PMC3662355.
[3]. Bush A, Gabriel R: The lungs in uraemia: a review. J R Soc Med 1985;78:849.
[4]. Conger JD, Hammond WS, Alfrey AC, Contiguglia SR, Stanford RE, Huffer WE. Pulmonary calcification in chronic dialysis patients. Clinical and pathologic studies. Ann Intern Med. 1975 Sep;83(3):330-6. doi: 10.7326/0003-4819-83-3-330. PMID: 1190631.
[5]. Gallagher-Lepak S. Functional capacity and activity level before and after renal transplantation. ANNA J. 1991 Aug;18(4):378-82; discussion 382, 406. PMID: 1872637.
[6]. Kalender B, Erk M, Pekpak MA, Apaydin S, Ataman R, Serdengeçti K, Sariyar M, Erek E; The effect of renal transplantation on pulmonary function, Nephron. 2002 Jan;90(1):72-7.
[7]. Shaffi K, Uhlig K, Perrone RD et al. Performance of creatininebased GFR estimating equations in solid-organ transplant recipients. Am J Kidney Dis 2014; 63: 1007–1018
[8]. Modified kuppuswamy socioeconomic scale updated for year 2019. Indian journal of forensic and community medicine, 2019;6(1).
[9]. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB. PMID: 12900694.
[10]. Cutoff Values for Normal Anthropometric Variables in Asian Indian Adults, Chamukuttan Snehalatha, Vijay Viswanathan, Ambady Ramachandran; Diabetes Care May 2003;26(5):1380-1384. DOI: 10.2337/diacare.26.5.1380
[11]. The Maximal Expiratory Flow-Volume Curve Normal Standards, Variability, and Effects of Age; Ronald j. Knudson, Ronald c. Slatin, Michael d. Lebowitz, and Benjamin Burrows, American review of respiratory disease, volume 1976;113.
[12]. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement, Brian L. Graham , Irene Steenbruggen , Martin R. Miller et al, American Journal of Respiratory and Critical Care Medicine, 2019;200(8). https://doi.org/10.1164/rccm.201908-1590ST, PubMed: 31613151
[13]. Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V, etal. Joint Indian Chest Society-National College of Chest Physicians (India) guidelines for spirometry. Lung India 2019;36:S1-35.
[14]. pvalue.io, a graphic user interface to the R statistical analysis software for scientific medical publications., 2020. Available on: https://www.pvalue.io
[15]. Sidhu J, Ahuja G, Aulakh B, Narang A, Whig J, Sidhu U. Changes in pulmonary function in patients with chronic renal failure after successful renal transplantation. Scand J Urol Nephrol. 2007;41(2):155-60. doi: 10.1080/00365590600991557. PMID: 17454956
[16]. Karacan O, Tutal E, Colak T, Sezer S, Eyüboğlu FO, Haberal M. Pulmonary function in renal transplant recipients and end-stage renal disease patients undergoing maintenance dialysis. Transplant Proc. 2006 Mar;38(2):396-400. doi: 10.1016/j.transproceed.2005.12.068. PMID: 16549130. A
[17]. Kalender B, Erk M, Pekpak MA, Apaydin S, Ataman R, Serdengeçti K, Sariyar M, Erek E. The effect of renal transplantation on pulmonary function. Nephron. 2002 Jan;90(1):72-7. doi: 10.1159/000046317. PMID: 11744808.
[18]. Bush A, Gabriel R. The lungs in uraemia: a review. J R Soc Med. 1985;78(10):849-855. doi:10.1177/014107688507801012
[19]. Fairshter RD, Vaziri ND, Farooqui S, Martin D. Pulmonary pathology in renal transplant recipients. Int J Artif Organs 1984;7:32730
[20]. Yanishi M, Kimura Y, Matsuda T et al; Factors associated with the development of sarcopenia in kidney transplant recipients. Transplant Proc 2017;49(2):288–292.
[21]. Sakuma K, Yamaguchi A. The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. J Biomed Biotechnol. 2010;2010:721219.
[22]. Sasan Tavana, Samaneh Mirzaei, The Effect of Renal Transplantation on Respiratory Muscle Strength in Patients with End Stage Renal Disease, National Research Institute of Tuberculosis and Lung Disease, Iran ISSN: 1735-0344 Tanaffos 2016; 15(2): 83-88
[23]. Yue Chen , Donna Rennie, Yvon F Cormier, James Dosman, Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects, Am J Clin Nutr, 2007 Jan;85(1):35-9. doi: 10.1093/ajcn/85.1.35
[24]. Barboza, Marcelo & Barbosa, Alan & Spina, Giovanna & Sperandio, Evandro & Arantes, Rodolfo & Gagliardi, Antonio & Romiti, Marcello & Dourado, Victor. (2016). Association between physical activity in daily life and pulmonary function in adult smokers. Jornal Brasileiro de Pneumologia. 42. 130-135. 10.1590/S1806-37562015000000102.
[25]. Painter P, Marcus RL. Assessing physical function and physical activity in patients with CKD. Clin J Am Soc Nephrol. 2013;8:861–72.

Cite this article: Harda Shah, Nehal Shah.  Pulmonary functions in kidney transplant recipients: Single centre observational study. Int J Physiother Res 2021;9(5):3986-3991. DOI: 10.16965/ijpr.2021.167

Post Views: 0