IJPR.2022.115

Type of Article:  Review

Volume 10; Issue 2 (April 2022)

Page No.: 4188-4203

DOI: https://dx.doi.org/10.16965/ijpr.2022.115

Homeostaticology, Iatrogenicology and Salutogenicology

R. Vinodh Rajkumar.

Physiotherapist, Medical Anthropologist & Gerontologist, Director – Prabhanjeet Fitness Research Institute OPC Private Limited, Bangalore, Karnataka, India. 
ORCiD: https://orcid.org/0000-0002-6656-3178

Corresponding Author: R.Vinodh Rajkumar, Physiotherapist, Medical Anthropologist & Gerontologist, Director – Prabhanjeet Fitness Research Institute OPC Private Limited, Bangalore, Karnataka, India.
E-Mail: dreamofkalam@rediffmail.com

ABSTRACT

Health may not be a perfect balance point but efforts can be made to maintain the health in a perfect homeostatic range. Disrupted homeostasis is the underlying issue of all the diseases. Larger and longer the deviations of the body from homeostatic conditions, poorer the ability to regain the original functions will be. George E Billman stated ‘Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology’. Lack of clinical diagnosis and treatments on the basis of homeostasis could lead to public health damage, disingenuous medical curriculum, and eventually iatrogenic pseudoscience. Ivan Illich criticized iatrogenesis caused by treatments, health policies, medicalization of life and eradication of autonomous coping skills during illnesses. Antonovsky distinctly stated that the salutogenesis was not limited by the disciplinary borders of one profession but rather an interdisciplinary approach and a question of bringing coherence between disciplines and realise what connects them through the people’s ability to comprehend the whole situation and the capacity to use the resources available [called as sense of coherence – SOC] to move in a health promoting direction. Prevention or healing of homeostatic disturbances obviously need interdisciplinary approach of various medical specializations including Physiotherapy. Intensifying impeccable prophylaxis, clinical applications and public health policies on the basis of homeostasis need in-depth and persistent emphasis on ‘Homeostaticology’, ‘Iatrogenicology’ and ‘Salutogenicology’.

Key words: Homeostasis, Iatrogenesis, Public health, Kinanthropometry, Salutogenesis, Stress, Eustress, Epigenetics, Exercise, Spiritual intelligence, Yerkes-Dodson Law.

REFERENCES

[1]. Von Ah Morano, AE, Dorneles, GP, Peres, A, Lira, FS. The role of glucose homeostasis on immune function in response to exercise: The impact of low or higher energetic conditions. J Cell Physiol. 2020; 235: 3169– 3188.
[2]. R.Vinodh Rajkumar. Perfect Homeostasis : pH. Int J Physiother Res 2022;10[1]:4111-4124.
[3]. R.Vinodh Rajkumar. Necessity of an Exclusive Health Care Model for Individuals with Quintessential Epigenetic Efficiency. Int J Physiother Res 2021; 9 [5]: 3992-4000.
[4]. Logan JG, Barksdale DJ. Allostasis and allostatic load: expanding the discourse on stress and cardiovascular disease. J Clin Nurs. 2008 Apr;17[7B]:201-8.
[5]. Li, Chun-Tung & Cao, Jiannong & Li, Tim M.H.. [2016]. Eustress or distress: an empirical study of perceived stress in everyday college life. 1209-1217.
[6]. Lazarus RS. From psychological stress to the emotions: a history of changing outlooks. Annu Rev Psychol. 1993;44:1-21.
[7]. Benson, H., and Allen, R. How much stress is too much? Harvard Business Review 58, 5 [1979], 86–92.
[8]. Cohen R.A. [2011] Yerkes–Dodson Law. In: Kreutzer J.S., DeLuca J., Caplan B. [eds] Encyclopedia of Clinical Neuropsychology. Springer, New York, NY.
[9]. Broadhurst, P. L. Emotionality and the Yerkes-Dodson Law. Journal of Experimental Psychology, 1957;54[5]: 345–352.
[10]. Sternberg EM. Walter B. Cannon and ” ‘Voodoo’ Death”: a perspective from 60 years on. Am J Public Health. 2002;92[10]:1564-1566.
[11]. Lindström B, Eriksson M. Salutogenesis. Journal of Epidemiology & Community Health 2005;59:440-442.
[12]. Jenny GJ, Bauer GF, Vinje HF, et al. The Application of Salutogenesis to Work. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, et al., editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 20.
[13]. Guillermo Fajardo-Ortiz, Miguel Ángel Fernández-Ortega, Armando Ortiz-Montalvo, Roberto Antonio Olivares-Santos, The dimension of the paradigm of complexity in health systems, Cirugía y Cirujanos [English Edition], 2015;83[1]:81-86.
[14]. Hagger MS, Wood C, Stiff C, Chatzisarantis NL. Ego depletion and the strength model of self-control: a meta-analysis. Psychol Bull. 2010 Jul;136[4]:495-525.
[15]. Beute, Femke & De Kort, Yvonne. Salutogenic Effects of the Environment: Review of Health Protective Effects of Nature and Daylight. Applied psychology. Health and well-being. 2013.
[16]. Sullivan-Singh SJ, Stanton AL, Low CA. Living with limited time: Socioemotional selectivity theory in the context of health adversity. J Pers Soc Psychol. 2015;108[6]:900-916.
[17]. Carstensen LL, Isaacowitz DM, Charles ST. Taking time seriously. A theory of socioemotional selectivity. Am Psychol. 1999 Mar;54[3]:165-81.
[18]. Prem Shankar Srivastava. Spiritual Intelligence: An Overview. International Journal of Multidisciplinary Research and Development. 2016; 3 [3]; 224-227
[19]. Dr.Jyoti Deepak Joshi, “Spiritual Intelligence” A Way of Life. International Journal of Scientific Research. 2016; 5[6], 339 – 341.
[20]. Illich I. Medical nemesis. Journal of Epidemiology & Community Health 2003;57:919-922.
[21]. Marta Michalska-Smith, MD. AMA J Ethics. 2017;19[8]:739-742.
[22]. Samuel Gorovitz, Alasdair MacIntyre, Toward a Theory of Medical Fallibility, The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 1976;1[1]:51–71.
[23]. Institute of Medicine [US] Committee on Quality of Health Care in America. To Err is Human: Building a Safer Health System. Kohn LT, Corrigan JM, Donaldson MS, editors. Washington [DC]: National Academies Press [US]; 2000. PMID: 25077248.
[24]. Labetoulle M. La iatrogénie: quelle ampleur, pourquoi et comment la réduire? [Iatrogeny: how prevalent is it, why, and how can it be reduced?]. J Fr Ophtalmol. 2009 Jan;32[1]:79-82. French.
[25]. Maharaj SR. Iatrogeny: why patients come to harm. West Indian Med J. 2010 Dec;59[6]:702-5.
[26]. Tessa Chelouche, MD. AMA J Ethics. 2021;23[1]:E59-63.
[27]. Adler RN, Smith J, Fishman P, Larson EB. To prevent, react, and rebuild: health research and the prevention of genocide. Health Serv Res. 2004;39[6 Pt 2]:2027-2051.
[28]. Baron JH. Doctors are still committing genocide. BMJ. 1999;319[7224]:1578.
[29]. Baron JH. Genocidal doctors. J R Soc Med. 1999;92[11]:590-593.
[30]. Billman GE. Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology. Front Physiol. 2020;11:200. Published 2020 Mar 10.
[31]. Torday JS. Homeostasis as the Mechanism of Evolution. Biology. 2015; 4[3]:573-590.
[32]. Modell H, Cliff W, Michael J, McFarland J, Wenderoth MP, Wright A. A physiologist’s view of homeostasis. Adv Physiol Educ. 2015;39[4]:259-266.
[33]. Palaparthi S [2017] Role of Homeostasis in Human Physiology: A Review. J Med Physiol Ther 1:101.
[34]. Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 2015;160[5]:816-827.
[35]. Mori G, D’Amelio P, Faccio R, Brunetti G. The Interplay between the bone and the immune system. Clin Dev Immunol. 2013;2013:720504.
[36]. Hygum K, Starup-Linde J, Langdahl BL. Diabetes and bone. Osteoporos Sarcopenia. 2019;5[2]:29-37.
[37]. Green J, Kleeman CR. Role of bone in regulation of systemic acid-base balance. Kidney Int. 1991 Jan;39[1]:9-26.
[38]. Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T. Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine. 2019 Nov;49:381-388.
[39]. Josep M. Argilés, Nefertiti Campos, José M. Lopez-Pedrosa, Ricardo Rueda, Leocadio Rodriguez-Mañas, Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease, Journal of the American Medical Directors Association, 2016;17[9]:789-796.
[40]. Abramowitz MK. Acid-base balance and physical function. Clin J Am Soc Nephrol. 2014;9[12]:2030-2032.
[41]. Bishlawy IM. Red blood cells, Hemoglobin and the immune system. Med Hypotheses. 1999 Oct;53[4]:345-6.
[42]. Rossing K, Christensen PK, Hovind P, Tarnow L, Rossing P, Parving HH. Progression of nephropathy in type 2 diabetic patients. Kidney Int. 2004 Oct; 66[4]:1596-605.
[43]. T. Rajini Samuel [July 18th 2019]. Who Is Balancing: Is It RBC or Acid-Base Status?, Erythrocyte, Anil Tombak, IntechOpen, DOI: 10.5772/intechopen.84768. Available from: https://www.intechopen.com/chapters/67465
[44]. Carpenter RH. Homeostasis: a plea for a unified approach. Adv Physiol Educ. 2004 Dec;28[1-4]:180-7.
[45]. Parfieniuk-Kowerda, Anna & Rogalska-Taranta, Magdalena & Pogorzelska, Joanna. The understanding of the term “iatrogeny”. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2006;20:365-6.
[46]. Peer RF, Shabir N. Iatrogenesis: A review on nature, extent, and distribution of healthcare hazards. J Family Med Prim Care. 2018;7[2]:-314.
[47]. Moutaouakkil Y, El jaoudi R, Ait el cadi M, Bennana A, Lamsaouri J, et al. [2017] Drug Iatrogenesis: A Review . Toxicol Open Access2017;3:129.
[48]. Robinson, Sherry RN, CS, PhD; Weitzel, Tina RN, BC, MA Going downhill, Nursing: April 2008;38[4]:62-63.
[49]. Darchy B, Le Mière E, Figuérédo B, Bavoux E, Domart Y. Iatrogenic Diseases as a Reason for Admission to the Intensive Care Unit: Incidence, Causes, and Consequences. Arch Intern Med. 1999;159[1]:71–78.
[50]. Titler MG. Technology dependency and iatrogenic injuries. Nurs Clin North Am. 1993 Jun;28[2]:459-73.
[51]. Bleakley, Alan. Communication Hypocompetence: An Iatrogenic Epidemic. 2014.
[52]. Fava G, A, Benasi G, Cosci F: The Potential Role of Iatrogenic Comorbidity in the Interaction between Pharmacotherapy and Psychotherapy in Anxiety Disorders. Verhaltenstherapie 2017;27:265-270.
[53]. Krishnan NR, Kasthuri AS. Iatrogenic Disorders. Med J Armed Forces India. 2005;61[1]:2-6.
[54]. BM Hegde. Weapons of Mass Destruction, http://www.bmhegde.com/wepon_masdistro.htm , accessed on 24.02.22.
[55]. Marshall JC. Critical illness is an iatrogenic disorder. Crit Care Med. 2010 Oct;38[10 Suppl]:S582-9.
[56]. Nazer LH, Brown ART, Awad W. Iatrogenic Toxicities in the Intensive Care Unit. Crit Care Clin. 2021 Jul;37[3]:625-641.
[57]. Ungureanu G, Alexa ID, Stoica O. Iatrogenia si vârstnicii [Iatrogeny and the elderly]. Rev Med Chir Soc Med Nat Iasi. 2007 Oct-Dec;111[4]:803-10.
[58]. Permpongkosol S. Iatrogenic disease in the elderly: risk factors, consequences, and prevention. Clin Interv Aging. 2011;6:77-82.
[59]. Thornlow DK, Anderson R, Oddone E. Cascade iatrogenesis: factors leading to the development of adverse events in hospitalized older adults. Int J Nurs Stud. 2009 Nov;46[11]:1528–35.
[60]. Cheng, B., Tian, J., Peng, Y. et al. Iatrogenic wounds: a common but often overlooked problem. Burn Trauma 2019;7:18.
[61]. Namèche L, Fillet M. [Iatrogenic risk in medical practice. About a clinical case report of urinary lithiasis.] Revue Medicale de Liege. 2021 Dec;76[12]:840-844.
[62]. Gild P, Kluth LA, Vetterlein MW, Engel O, Chun FKH, Fisch M. Adult iatrogenic ureteral injury and stricture-incidence and treatment strategies. Asian J Urol. 2018;5[2]:101-106.
[63]. Blum D, Chan CT. Iatrogenesis Imperfecta Medicamentosa: Adverse Drug Events in Dialysis Patients are Associated with Higher Resource Utilization and Mortality. Am J Nephrol. 2018;47[6]:438-440.
[64]. P.D. Donofrio, C.D. Clarke. Neuropathies, Iatrogenic. Encyclopedia of the Neurological Sciences [Second Edition], Academic Press, 2014;481-484.
[65]. Mehta CR, Constantinidis A, Farhat M, Suthersan M, Graham E, Kanawati A. The distance of the femoral neurovascular bundle from the hip joint: an intraoperative guide to reduce iatrogenic injury. J Orthop Surg Res. 2018 Jun 4;13[1]:135.
[66]. Khaskheli MN, Baloch S, Sheeba A. Iatrogenic risks and maternal health: Issues and outcomes. Pak J Med Sci. 2014;30[1]:111-115.
[67]. Andrews, B. Neonatology–A Six Finger Exercise Revisited 149. Pediatr Res 1998;43:28
[68]. Palmieri PA, Peterson LT, Ford EW. Technological iatrogenesis: new risks force heightened management awareness. J Healthc Risk Manag. 2007;27[4]:19-24.
[69]. “Iatrogenesis”, A Dictionary of Sociology, Encyclopedia.com. updated 31 May 2020.
[70]. S O’Mahony. Medical Nemesis 40 years on: the enduring legacy of Ivan Illich. J R Coll Physicians Edinb 2016; 46: 134–9.
[71]. Smith R. Limits to medicine. Medical nemesis: the expropriation of health. Journal of Epidemiology & Community Health. 2003;57:928.
[72]. Mittelmark MB, Bauer GF. The Meanings of Salutogenesis. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, Bauer GF, Pelikan JM, Lindström B, Espnes GA, editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 2. PMID: 28590655.
[73]. Eriksson M. The Sense of Coherence in the Salutogenic Model of Health. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, Bauer GF, Pelikan JM, Lindström B, Espnes GA, editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 11. PMID: 28590620.
[74]. Mazzi A. Toward a Unified Language [and Application] of Salutogenic Design: An Opinion Paper. HERD. 2021 Apr;14[2]:337-349.
[75]. Bauer GF, Roy M, Bakibinga P, Contu P, Downe S, Eriksson M, Espnes GA, Jensen BB, Juvinya Canal D, Lindström B, Mana A, Mittelmark MB, Morgan AR, Pelikan JM, Saboga-Nunes L, Sagy S, Shorey S, Vaandrager L, Vinje HF. Future directions for the concept of salutogenesis: a position article. Health Promot Int. 2020 Apr 1;35[2]:187-195.
[76]. Benz C, Bull T, Mittelmark M, Vaandrager L. Culture in salutogenesis: the scholarship of Aaron Antonovsky. Glob Health Promot. 2014 Dec;21[4]:16-23.
[77]. Pelikan JM. The Application of Salutogenesis in Healthcare Settings. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, Bauer GF, Pelikan JM, Lindström B, Espnes GA, editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 25.
[78]. Quehenberger V, Krajic K. Applications of Salutogenesis to Aged and Highly-Aged Persons: Residential Care and Community Settings. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, Bauer GF, Pelikan JM, Lindström B, Espnes GA, editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 31. PMID: 28590628.
[79]. Smith V, Daly D, Lundgren I, Eri T, Benstoem C, Devane D. Salutogenically focused outcomes in systematic reviews of intrapartum interventions: a systematic review of systematic reviews. Midwifery. 2014 Apr;30[4]:e151-6.
[80]. Perez-Botella M, Downe S, Magistretti CM, Lindstrom B, Berg M. The use of salutogenesis theory in empirical studies of maternity care for healthy mothers and babies. Sex Reprod Healthc. 2015 Mar;6[1]:33-9.
[81]. Fekete OR, Kinn LG, Larsen TMB, Langeland E. Salutogenesis as a theoretical framework for psychosocial rehabilitation: the case of the Clubhouse model. Int J Qual Stud Health Well-being. 2020 Dec;15[1]:1748942.
[82]. Klein, D. and Vogt, T. A Salutogenic Approach to Physical Education in Schools. Advances in Physical Education, 2019;9:188-196.
[83]. Bhattacharya, Sudip; Pradhan, Keerti Bhusan; Bashar, Md Abu; Tripathi, Shailesh; Thiyagarajan, Arulmani; Srivastava, Abhay; Singh, Amarjeet. Salutogenesis, Journal of Family Medicine and Primary Care: January 2020;9[1]:16-19.
[84]. Jacob H. Why all doctors should be involved in research BMJ 2016; 352 :i164
[85]. Thiese MS, Walker S, Lindsey J. Truths, lies, and statistics. J Thorac Dis. 2017;9[10]:4117-4124.
[86]. Light DW, Lexchin J, Darrow JJ. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs. J Law Med Ethics. 2013 Fall;41[3]:590-600.
[87]. Muris P, Merckelbach H, Otgaar H, Meijer E. The Malevolent Side of Human Nature. Perspect Psychol Sci. 2017 Mar;12[2]:183-204.
[88]. Shahar J, Hamdy O. Medication and exercise interactions: considering and managing hypoglycemia risk. Diabetes Spectr. 2015;28[1]:64-67.
[89]. R.Vinodh Rajkumar. Lungeometry – Geometrical investigation of lunge. International Journal of Physiotherapy and Research 2015;3[1]:855-862.
[90]. Katzenbach JR, Smith DK. The discipline of teams.Harv Bus Rev. 1993 Mar-Apr; 71[2]:111-20.
[91]. Lencioni P. The Five Dysfunctions of a Team. Jossy-Bass, A Wiley Imprint. 2007
[92]. Jeste DV, Lee EE, Cassidy C, et al. The New Science of Practical Wisdom. Perspect Biol Med. 2019;62[2]:216-236.
[93]. LaDonna, Kori A. PhD; Ginsburg, Shiphra MD, PhD; Watling, Christopher MD, PhD “Rising to the Level of Your Incompetence”: What Physicians’ Self-Assessment of Their Performance Reveals About the Imposter Syndrome in Medicine, Academic Medicine: May 2018;93[5]:763-768.
[94]. Gupta P. Humanity in medicine. J Med Ethics Hist Med. 2011;4:3. Published 2011 Feb 27.
[95]. Stern, E. Individual differences in the learning potential of human beings. npj Science Learn 2017;2:2.
[96]. Al-Eisa ES, Al-Hoqail H, Al-Rushud AS, et al. Awareness, perceptions and beliefs about physiotherapy held by physicians working in Saudi Arabia: a cross-sectional study. J Phys Ther Sci. 2016;28[12]:3435-3439.
[97]. R.Vinodh Rajkumar. Resisting Morbidity and Mortality [RMM]: An Equitable Public Health. Int J Physiother Res 2020; 8 [6]: 3693-3705.
[98]. Mittelmark MB, Bull T, Daniel M, et al. Specific Resistance Resources in the Salutogenic Model of Health. 2016 Sep 3. In: Mittelmark MB, Sagy S, Eriksson M, et al., editors. The Handbook of Salutogenesis [Internet]. Cham [CH]: Springer; 2017. Chapter 8. Available from: https://www.ncbi.nlm.nih.gov/books/NBK435842/ doi: 10.1007/978-3-319-04600-6_8
[99]. Chaiklin, Harris Ph.D. Unraveling the Mystery of Health: How People Manage Stress and Stay Well, The Journal of Nervous and Mental Disease: July 1989;177[7]:439-440.
[100]. Genuis SJ, Sears ME, Schwalfenberg G, Hope J, Bernhoft R. Clinical detoxification: elimination of persistent toxicants from the human body. ScientificWorldJournal. 2013;2013:238347.
[101]. Razis DV. The risk of a sixth mass extinction of life and the role of medicine. J R Soc Med. 2010;103[12]:473-474.

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