IJAR.2021.138
Type of Article: Original Research
Volume 9; Issue 3.3 (September 2021)
Page No.: 8079-8085
DOI: https://dx.doi.org/10.16965/ijar.2021.138
Measurement of Corpus Callosum Size Using MRI In Nepalese Population
Suman Gnawali *1,2, Ajay Kumar Yadav 1, Mukunda Psd Humagain 2, Prakash Kayastha 2, Durga Panthi 3.
*1 Department of Radio diagnosis, Imaging and Nuclear Medicine, B.P.Koirala Memorial Cancer Hospital, Chitwan, Nepal.
2 Department of Radiology &Imaging, TU Teaching Hospital, Kathmandu, Nepal.
3 Institute of Medicine, Central Department Of Public Health, Kathmandu, Nepal.
Corresponding Author: Suman Gnawali, Department of Radio diagnosis, Imaging and Nuclear Medicine , B.P.Koirala Memorial Cancer Hospital, Chitwan, Nepal. E-Mail: suman.gnawali987@gmail.com
ABSTRACT
Corpus callosum (CC) is the main fiber tract connecting the cortical and sub-cortical regions of the right, left hemispheres, and plays an essential role in the integration of information between the two hemispheres. By using magnetic resonance imaging (MRI), the dimensions of corpus callosum can be studied. In this cross-sectional quantitative study 80 cases of normal MRI head were selected for study over two months. T1 weighted sagittal spin-echo images with slice thickness of 6 mm, planned from an axial and coronal image were used for measuring length and thickness of corpus callosum. Obtained data were analyzed using SPSS ver.20 software and shown in frequency, percentages and bar diagram. The mean Corpus callosum (CC) length was 68.06 mm in the study population (n=80). The mean thickness of Genu, Body and Splenium were 9.15,5.2 and 9.08 mm respectively and average thickness was 7.81 mm. Statistically significant differences in size of CC for various age groups in both sexes were observed. The mean length of CC was 68.06 mm and mean thickness of CC was 7.81 mm. There were variation in the size of CC with age and sex. The Pearson correlation Coefficient is 0.48829 between Age and Length of CC, its P-value is 0.0019
Key word: Magnetic Resonance Imaging (MRI), Corpus callosum (CC), Genu, Body, Splenium Sagittal Spin-Echo.
REFERENCES
[1]. Takeda S, Hirashima Y, Ikeda H, Yamamoto H, Sugino M, Endo S. Determination of indices of the corpus callosum associated with normal aging in Japanese individuals. Neuroradiology. 2003;45(8):513–8.
[2]. Suganthy J, Raghuram L, Antonisamy B, Vettivel S, Madhavi C, Koshi R. Gender- and age-related differences in the morphology of the corpus callosum. Clin Anat. 2003;16(5):396–403. doi: 10.1002/ca.10161.
[3]. Gupta T, Singh B, Kapoor K, Gupta M, Kochhar S. Age and sex related variations in corpus callosal morphology. Nepal Med Coll J. 2008;10(4):215–21.
[4]. Bermudez P, Zatorre RJ. Sexual dimorphism in the corpus callosum: methodological considerations in MRI morphometry. Neuroimage. 2001;13(6 Pt 1):1121–30. doi: 10.1006/nimg.2001.0772.
[5]. Mourgela S, Anagnostopoulou S, Sakellaropoulos A, Gouliamos A. An MRI study of sex-and age-related differences in the dimensions of the corpus callosum and brain. Neuroanatomy. 2007;6(1):63–5.
[6]. Yamauchi H, Fukuyama H, Shio H. Corpus callosum atrophy in patients with leukoaraiosis may indicate global cognitive impairment. Stroke. 2000;31(7):1515–20. doi: 10.1161/01.STR.31.7.1515.
[7]. Tomaiuolo F, Di Paola M, Caravale B, Vicari S, Petrides M, Caltagirone C. Morphology and morphometry of the corpus callosum in Williams syndrome: a T1-weighted MRI study. Neuroreport. 2002;13(17):2281–4. doi: 10.1097/00001756-200212030-00022.
[8]. von Plessen K, Lundervold A, Duta N, Heiervang E, Klauschen F, Smievoll AI, et al. Less developed corpus callosum in dyslexic subjects– a structural MRI study. Neuropsychologia. 2002;40(7):1035– 44 doi: 10.1016/S0028-3932(01)00143-9.
[9]. Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, et al. Altered interhemispheric connectivity in individuals with Tourette’s disorder. Am J Psychiatry. 2004;161(11):2028–37. doi: 10.1176/appi.ajp.161.11.2028.
[10]. Teipel SJ, Schapiro MB, Alexander GE, Krasuski JS, Horwitz B, Hoehne C, et al. Relation of corpus callosum and hippocampal size to age in nondemented adults with Down’s syndrome. Am J Psychiatry. 2003;160(10):1870–8. doi: 10.1176/appi.ajp.160.10.1870.
[11]. Lacerda AL, Brambilla P, Sassi RB, Nicoletti MA, Mallinger AG, Frank E, et al. Anatomical MRI study of corpus callosum in unipolar depression. J Psychiatr Res. 2005;39(4):347–54. doi: 10.1016/j.jpsychires.2004.10.004.
[12]. Narr KL, Cannon TD, Woods RP, Thompson PM, Kim S, Asunction D, et al. Genetic contributions to altered callosal morphology in schizophrenia. J Neurosci. 2002;22(9):3720–9.
[13]. Thompson PM, Dutton RA, Hayashi KM, Lu A, Lee SE, Lee JY, et al. 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. Neuroimage. 2006;31(1):12–23. doi: 10.1016/j.neuroimage.2005.11.043.
[14]. Peterson BS, Feineigle PA, Staib LH, Gore JC. Automated measurement of latent morphological features in the human corpus callosum. Hum Brain Mapp. 2001;12(4):232–45. doi: 10.1002/1097-0193(200104)12:4<232::AID-HBM1018>3.3.CO;2-A.
[15]. Luders E, Narr KL, Zaidel E, Thompson PM, Toga AW. Gender effects on callosal thickness in scaled and unscaled space. Neuroreport. 2006;17(11):1103–6. doi: 10.1097/01.wnr.0000227987.77304.cc.
[16]. Sullivan EV, Pfefferbaum A, Adalsteinsson E, Swan GE, Carmelli D. Differential rates of regional brain change in callosal and ventricular size: a 4-year longitudinal MRI study of elderly men. Cereb Cortex. 2002;12(4):438–45. doi: 10.1093/cercor/12.4.438.
[17]. Luders E, Rex DE, Narr KL, Woods RP, Jancke L, Thompson PM, et al. Relationships between sulcal asymmetries and corpus callosum size: gender and handedness effects. Cereb Cortex. 2003;13(10):1084–93. doi: 10.1093/cercor/13.10.1084.
[18]. Estruch R, Nicolas JM, Salamero M, Aragon C, Sacanella E, Fernandez-Sola J, et al. Atrophy of the corpus callosum in chronic alcoholism. J Neurol Sci. 1997;146(2):145–51. doi: 10.1016/S0022-510X(96)00298-5.
[19]. Mohammadi MR, Zhand P, Mortazavi Moghadam B, Golalipour MJ. Measurement of the corpus callosum using magnetic resonance imaging in the north of iran. Iran J Radiol. 2011 Dec;8(4):218-23. doi: 10.5812/iranjradiol.4495. Epub 2011 Dec 25. PMID: 23329944; PMCID: PMC3522367.
