CYTOGENETIC ANALYSIS OF PREMATURE OVARIAN FAILURE PATIENTS Ashish Sharma * 1 , Tarsem kumar 2 ,  Rima dada 3 . *1 Assistant Professor, Department of Anatomy,  MRA Medical College,  Ambedkar Nagar (U.P), India . 2  Demonstrator, Department of Anatomy,  MRA Medical College, Ambedkar Nagar(U.P), India . 3  Additional Professor, Department of Anatomy,  All India Institute of Medical Science (AIIMS), New Delhi, India Address   for   Correspondence:   Dr.   A.Sharma,   Assistant   Professor,   Department   of   Anatomy,      MRA   Medical   College,      Ambedkar   Nagar   (U.P),   India .    E-Mail:   ashish7644@gmail.com ABSTRACT Premature   ovarian   failure   (POF)   is   defined   as   amenoirhea   for   more   than   6   months   in   the   presence   of   raised   gonadotrophins,   FSH   serum   level   higher   than   40 mIU/ml,   occulting   before   the   age   of   40.   In   this   study,   we   have   done   karyotyping   of   POF   patients.   The   findings   which   consist   of   55%   Karyotype   abnormality are   17%   46,X0,   4%   46,XX(Xr),   20%   46XX(Xq   del),   6%   46,XX(Xinv),   6%   47,XXX   and   2%   46,XX(Xqiso).The   (mean   ±   S.D.)   height   of   all   the   POF   patient   142.5±0.18 and   the   (mean   ±   S.D.)   FSH   of   all   the   POF   patients   45.21±17.41.   As   we   have   correlated   the   finding   especially   Xqdel   and   XO   the   (mean   ±   S.D.)   height(ft)   4ft 8inch   ±   0.39   and   4ft6inch   ±   0.21,   respectively   .   The   hormonal   level   FSH   especially   Xqdel   and   XO   The   (mean   ±   S.D.)   FSH   (mIU)   93±   31.91   and   92.66   ±   23.75, respectively.   The   chromosomal   abnormality   especially   turner   syndrome,   X-chromosomal   abnormality   associated   with   POF   patients   as   shown   by   this   study. 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