PLACENTAL CO-EFFICIENT IN NEPALESE POPULATION  AND IT’S CLINICAL RELEVANCE Shekhar Kumar Yadav * 1 , Ratindra  Nath  Shrestha 2 , Arun Dhakal 3 , Gulam Anwer Khan 4 . *1 Assistant Professor, Department of Anatomy, Chitwan Medical College, Bharatpur, Nepal. 2  Professor and HOD, KIST Medical College, Kathmandu, Nepal. 3 Assistant Professor, Chitwan Medical College, Bharatpur, Nepal. 4  Assistant   Professor, Department of Anatomy, Chitwan   Medical College, Bharatpur, Nepal. Address   for   the   Correspondence:    Dr.   Shekhar   Kumar   Yadav,   Assistant   Professor,   Department   of   Anatomy,   Chitwan   Medical   College,   Bharatpur,   Nepal.   E- Mail:   shekhar_np1@hotmail.com ABSTRACT Background:   The   placenta   is   a   functional   unit   between   the   mother   and   the   fetus.   Placental   coefficient   is   a   method   to   correlate   the   weight   of   a   baby   and   the placenta.   Any   pathological   events         that   concern   the   mother   and   the   fetus   tend   to   influence   the   normal   function   of   the   placenta   as   revealed   in   different studies by many authors. Aim :The   aim   of   the   study   was   to   examine   and   assess   placental   coefficient   of   the   normal   placenta   and   also      in   pathological   conditions   which   included diabetes mellitus, anaemia and hypertension. Materials   and   Methods:    The   freshly   delivered   placentas   for   this   study   were   obtained   from   department   of         Gynaecology      and      Obstetrics,   Tribhuvan Hospital      Teaching      Hospital.   The   study   was   conducted   on   a   total   of   100   freshly   obtained   placenta,   out   of   them,   15   were   from   diabetic   mothers,   15   from anaemic   mothers   and   15   from   hypertensive   mothers.   The   placental   co-efficient   was   obtained   by   dividing   placental   weight   in   grams   by   birth   weight   in grams. Results:      The   mean   weight   of   placenta   was   546.9   ±   of   81.38   gm.   The   mean   neonatal   weight   was   3.00±0.4kg.      The   result   shows   statistically   significant difference   between   weight   of   placenta   (p=0.001)   and   placental   coefficient   (p=0.001)   of   anemic   and   non-anemic   mothers.   Similarly   statistically   significant difference    was    obtained    between    weight    of    placenta    (P=0.003)    and    neonatal    weight    in    diabetic    (P=0.016)    and    non    diabetic.    Statistically    significant difference was not observed in hypertensive and normotensive  placenta. Conclusion:    Findings   of   the   study   shows   the   assessment         of   placenta   very   much   essential   as   normal   pregnancies   can   also   show   significant   placental changes.   Systemic   illness   alters   the   placental   morphology   and   adequate   treatment   of   systemic   illness   may   therefore   be   necessary         to         normal   placental function. KEY WORDS: Placenta, Parameters, Diabetes mellitus, Anaemia, Hypertension. References 1 . Kouvalainen K, Pynnonen Al, Makarainen M,Peltonen T.Weights of placental membranes and umbilical cord.Duodecim.1971;87:1210-1214. 2 . Raghunath   G,   Vijayalaxmi,   Shenoy   V.   A   study   on   the   Morphology   and   the   Morphometry   of   the   Human   Placenta   and   its   Clinical   Relevance   in   a population in Tamilnadu. Journal of Clinical and Diagnostic Research. 2011 Apr;5(2):282-286. 3 . Clavero JA, Botella Llusia J. 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